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(2) Overall, dutasteride is thought to be a safe and highly effective hair loss treatment. In conclusion, findings from this study provide real-world evidence of the effectiveness and safety of dutasteride versus finasteride in the treatment of AGA among patients treated for ≥3 years in South Korea. These results support treatment with dutasteride among patients with various levels of AGA severity, especially those with the most common type of AGA (M type).
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You can have a free online minute questionnaire-based appointment with our doctors today to see if Dutasteride is a good choice for you. A cancer treatment drug called ceritinib and an antibiotic called clarithromycin can both interact with dutasteride. There is a possibility that taking this medication can increase a person’s risk of developing fast-spreading prostate cancer.
Oral Dutasteride for Hair Loss
It’s important to do your research and consult your doctor before starting any combination treatment. Patients may combine dutasteride with natural DHT blockers, such as saw palmetto, to try to improve their outcomes. Natural options may be taken as supplements or used topically while taking oral dutasteride. (30) It’s important to note these natural combinations are not well researched or proven to be safe.
What are the side effects of dutasteride?
Effectiveness and safety data were extracted from patient charts at the index date and at each patient visit during the observation period. Improvement in BASP classification was defined as any decrease in grades of the basic (e.g. M3 to M2) or specific (e.g. V3 to V1) type compared with baseline14,16,17. After scrutinizing their abstracts and titles, we ruled out 66 articles.
Treatments for Alopecia and Hair Loss
In common with all medications, dutasteride can cause side effects in some people. Some side effects of dutasteride may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. However, since this is an off-label indication, we do not have many studies that will help doctors conclusively determine the best dose and schedule of Dutasteride to use for the best hair benefits. Risk of bias assessment of the included studies according to the Cochrane guidelines.
Of the remaining ten articles, seven articles were excluded due to lack of effective data. Finally, three articles containing three RCTs15–17 that analyzed dutasteride vs finasteride in treating men with AGA were included in our study. The baseline characteristics of three studies are summarized in Table 1. We performed a meta-analysis to evaluate the efficacy and safety of dutasteride and finasteride in treating AGA during a 24-week treatment cycle. “Spironolactone is an anti-androgen oral medication that regulates hormones and is particularly useful for female patients with PCOS,” she notes. It aids in hair growth because it can reduce the production of male hormones.
Renal Dose Adjustments
The lower proportions observed here may be because sexual AEs are not recorded by dermatologists in the real world in the same way as in clinical trials. SAEs were reported infrequently and were equivalent between treatment groups, consistent with the South Korean post-marketing surveillance study, which found SAEs occurred among 0.6% of dutasteride-treated patients15. Our study supports a similar or potentially slightly better safety profile of dutasteride compared with finasteride.
Natural DHT blockers are also available, such as the popular nutraceutical saw palmetto. Saw palmetto is an extract that comes from the berries of a type of palm tree. Other nutraceutical DHT blockers include stinging nettle, pumpkin seed oil, lycopene, tea tree oil, and caffeine. Dutasteride is a medication that doctors usually give to people with enlarged prostates.
In another study by the American Academy of Dermatology, 917 men aged 20 to 50 with androgenetic alopecia were randomized to receive either dutasteride (0.02, 0.1, or 0.5mg/d), finasteride (1mg/d), or a placebo for 24 weeks. The results from the study are corroborated by recent data released by JAMA Dermatology, which concluded that oral dutasteride outperforms every other male hair loss treatment currently available. Current research indicates the potential for oral dutasteride to be the next big medication to treat male pattern baldness. It is not currently FDA approved but may soon be as more studies are underway.
When applied topically, it works by stopping DHT conversion in the hair follicles. Both of these treatments block 5-AR, however, Pimstone points out that dutasteride inhibits two forms of the enzyme known as isoforms I and II, whereas finasteride only acts on isoform II. According to Agbai, genetics, hormonal shifts, stress, underlying medical conditions, nutritional deficiencies, and scalp inflammation are notable factors. If you’ve noticed an excessive amount of hair shedding, a receding hairline, or that the hair on the crown of your head becoming increasingly sparse, you’re probably experiencing a form of hair loss. Losing your hair can be a distressing experience, but you’re not alone. Finally, keep in mind that the same healthy habits recommended for maintaining your physical health will also help your hair.
Future studies should focus on establishing the optimal number of treatments and dosages, frequency, administration techniques, and overall safety. According to the Cochrane RoB 2.0 criteria, 1 study was ranked having a high risk of bias [19] and 3 having some concerns of bias [20, 21, 22] concerning the randomization process. Subsequently, 3 other studies were ranked as having some concerns of bias [18, 19, 22] in the deviations from intended intervention domain. Regarding missing outcome data, 1 trial exhibited high risk of bias [20]. With respect to the measurement of the outcome criteria, 3 studies were ranked as having high risk of bias [18, 19, 22] and 1 study having some concerns [20].
Scarring alopecia is the most devastating type of hair loss, Mirmirani says, because it permanently destroys the hair follicles. Oliva offers advanced hair loss treatments in Hyderabad, Bangalore, Chennai, Kolkata, Pune, Vizag and Kochi. Recommended by expert dermato-trichologists worldwide, Dutasteride is considered the best oral treatment to fight against hair loss. If you are losing more hair than you should, then try this powerful antidote and save your hair. In one double-blind study, 2/70 patients on 0.5mg daily had decreased libido, and 2/70 had impotence.
Hair loss and prostate drugs linked to persistent erectile dysfunction in men - Northwestern Now
Hair loss and prostate drugs linked to persistent erectile dysfunction in men.
Posted: Thu, 09 Mar 2017 08:00:00 GMT [source]
As a globally recognized leader in the field of cosmetic dermatology for over 25 years, Dr. Green will make recommendations for your personalized treatment plan for hair loss based on her evaluation of your condition. Dr. Green will carefully construct a treatment approach that is best suited to addressing your situation and that incorporates the in-office procedures, prescription medications, and topical treatments that will work best for you. Oral dutasteride is a prescription drug commonly known by its brand name Avodart. It blocks the action of an enzyme called 5-alpha-reductase and is part of a class of medications known as 5-alpha-reductase inhibitors. This class of drugs prevents your body from converting testosterone into an androgen hormone called dihydrotestosterone (DHT) which has been linked to male pattern hair loss. DHT plays a major role in the development of male sex characteristics such as facial and body hair.
