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DHT blockers help to stop hair loss and allow hair to regrow over time. Dutasteride varies in price depending on where you live and how you access your medication. In Japan, where dutasteride is approved to treat hair loss, prices average at JP¥11,500 for 30 pills. A person should inform a doctor of any allergies they have, any medications they are taking, and medical conditions they have, such as liver disease or prostate cancer. Androgenic alopecia (AGA) is an androgen-dependent progressive hair loss condition with genetic predisposition, affecting up to 70% of men during their lifetime1,2.
Associated Data
Safety profiles were largely equivalent, with equivalence demonstrated in several AEs, including skin disorders. Data from this study suggest that dutasteride may be more beneficial compared with finasteride in the treatment of AGA in some male patients, in line with results from prior RCTs7,8,19. Our results indicate that dutasteride is effective and well tolerated when prescribed at the recommended dose (0.5 mg/day). The present study showed that dutasteride and finasteride were relatively well-tolerated. Considering possible sexual dysfunction, mainly including altered libido, ED, and ejaculation disorders, the dutasteride group showed no statistical differences compared with the finasteride group.
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Topical finasteride is applied directly to the scalp, which may lower systemic side effects like sexual dysfunction. Spironolactone competitively inhibits the androgen receptor and also inhibits ovarian production of androgens. Of the antiandrogen drugs used off-label, it is the one most commonly used.
substantial weight loss over a short period of time
An alternative approach would have been to group BASP types together to define ‘mild’ (M1–2, C1, V1–2, F1–3), ‘moderate’ (M3, C2, V3) and ‘severe’ (C3, U1–3) AGA, but this lacks the specificity required to detect improvements in AGA. Additional measures of hair loss were investigated, including total hair count and hair diameter (data not shown); however, these data were too sparse to reach adequate statistical power. Patients were excluded if they received any prescription of dutasteride ≤12 weeks prior to finasteride initiation or any prescription of finasteride ≤8 weeks prior to dutasteride initiation. Dutasteride (0.5 mg/day) is approved for treatment of AGA in South Korea, Japan, and Taiwan11,12,13.
Does Dutasteride Have Side Effects?
Randomized controlled trials of dutasteride and finasteride for treating AGA were searched using MEDLINE, EMBASE, and the Cochrane Controlled Trials Register. Meanwhile, the results of an older randomized placebo-controlled study of dutasteride versus finasteride, found that the former was more effective in increasing target area hair count. The treatment which is primarily used to treat benign prostatic hyperplasia (BPH) in men with an enlarged prostate, is sometimes prescribed off-label as a treatment for hair loss as well.
Men between 18 and 40 years of age either received 0.5mg dutasteride or 1mg finasteride daily for 24 weeks. Hair counts at the start of the study and at the 24 week follow-up were measured in total hair counts per cm². The baseline for the dutasteride group was 223 and was 246 after 24 weeks, while the baseline for the finasteride group was 227 and 231 after 24 weeks. There was significantly more hair growth with the use of dutasteride as compared to finasteride. The effectiveness results reported here are consistent with a systematic review of three clinical trials investigating the efficacy of dutasteride and finasteride in male AGA over 24 weeks.
Above all, dutasteride seems to provide a better efficacy compared with finasteride, and two drugs appear to show similar rates of adverse reactions, especially with respect to sexual dysfunction. In terms of dosage, there is no uniform fixation for both drugs at present. Clinically, dutasteride (0.5 mg per day) and finasteride (1 mg per day) have been used by some doctors to treat AGA and have showed good therapeutic effect. Further clinical studies are needed to explain the effect of different dosage of drugs in treating AGA. But most of those studies were small, and long-term safety and effectiveness for women remains unclear.
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The plot was highly symmetrical and three squares were contained in the large triangle, and no evidence of bias was found (Figure 2). “Typically men want to get ahead of their hair loss as early intervention and early treatment will allow for best results,” he explains. “With this extensive clinical experience, we are not aware of any serious adverse reactions that have highlighted significant risks with oral formulations,” he concludes. Some potential side effects include skin and scalp irritation, cold sweats, and dizziness. When compared to finasteride, Pimstone says dutasteride is a far more active inhibitor of the 5-AR enzyme and hence has a more potent effect in lowering DHT levels.
Intake of Dutasteride 0.5 mg has shown positive results in terms of reducing hair loss by 96%. Some doctors may already be aware of the potential off-label usage, or they may rather start with Finasteride or Minoxidil for hair loss. If you are interested in seeing if Dutasteride off-label for hair loss is a good option for you, start with talking to your doctor. This may be a singular treatment consisting of just the Dutasteride, or sometimes the Dutasteride 0.5mg capsule will also be paired with another prostate medication, Tamsulosin. When you are using Dutasteride for an enlarged prostate, the doctor will normally prescribe the 0.5mg capsule to be taken once every day. Our capsules generally come in the 0.6mg strength, and our topical formulation can be compounded with up to 1mg of Dutasteride per gram.
If a female, child, or adolescent comes into contact with the inside of the medication, they must wash their hands immediately. Doctors only prescribe finasteride to treat type 2, whereas dutasteride can treat both types. The data that support the findings of this study (individual participant data and study documents) are available from upon reasonable request. All authors contributed to data analysis, drafting or revising the article, gave final approval of the version to be published, and agree to be accountable for all aspects of the work. A systematic review of randomized controlled trials (RCTs) was carried out using the PRISMA11 checklist. Hair products that contain essential oils of peppermint, rosemary, and lavender may also help to rejuvenate the hair follicles.
However, efficacy and safety data for dutasteride is largely derived from short-term clinical trials and post-marketing surveillance studies6,7,8,14,15,16. Long-term, real-world evidence for the effectiveness of dutasteride is limited. We performed a meta-analysis to evaluate the efficacy and safety of dutasteride and finasteride in treating men with androgenetic alopecia (AGA) during a 24-week treatment cycle. Dutasteride is mainly used to fight hair fall, however it can also be used to regrow hair as well. Men suffering from male pattern baldness have high levels of dihydrotestosterone or simply, DHT.
The benefit of working with a board-certified dermatologist, like Dr. Michele Green in NYC, is that you have an expert in the field to advise on the medications and treatments that are best suited to your situation. When you consult with Dr. Green at her private dermatology office in the Upper East Side neighborhood of Manhattan, she will collect a thorough medical history and physically evaluate your hair loss. Lab tests may be ordered to better understand the factors contributing to your hair loss and hair thinning. Based upon the discussion and findings, you will be recommended the treatments, medications, and procedures that will best help you grow and retain hair.
Male AGA is characterised by receding temporal hairlines and hair loss at the whorl and/or vertex of the head2. AGA causes self-image dissatisfaction and impaired overall quality of life3. Currently, there is not enough evidence to show the merit and demerit of the two drugs. The good news is, when it comes to hair loss, dutasteride has shown promising clinical effectiveness, is generally safe for use, and is now more accessible than ever. Finally, Green points to platelet-rich plasma (PRP) as a non-surgical approach for both male and female-pattern hair loss. It’s also important to note that dutasteride is not FDA-approved as a hair loss treatment so you’ll need to exercise extra caution if using it for this purpose.
In addition, 4 studies revealed some concerns in the selection of the reported results [18, 19, 20, 22]. Finally, 4 studies showed high risk of bias [18, 19, 20, 22], 1 had some concerns [20] for overall bias, and 3 were ranked as having a low risk of bias [16, 17, 23]. Of these, 688 studies were excluded because they did not meet the inclusion criteria.
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